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Checkout the complete overview of the book Antibiotics: Challenges, Mechanisms, Opportunities 2nd Edition PDF:
Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.
This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics.
Features of Antibiotics: Challenges, Mechanisms, Opportunities 2nd Edition PDF
Here’s a quick overview of the essential features of this book:
Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:
- What are antibiotics?
- Where do antibiotics come from?
- How do antibiotics work?
- Why do antibiotics stop working?
- How should our limited inventory of effective antibiotics be addressed?
Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
Table of Contents
Below is the full table of contents offered inside Antibiotics: Challenges, Mechanisms, Opportunities 2nd Edition PDF:
Section I Challenges for Antibiotics
1 Antibiotics: Initial Concepts and Considerations
2 Major Classes of Antibiotics and Their Modes of Action
Section II Mechanisms: Antibiotic Action by Bacterial Target Class
3 Assembly of the Peptidoglycan Layer of Bacterial Cell Walls
4 Antibiotics That Block Peptidoglycan Assembly and Integrity
5 Antibiotics That Disrupt Membrane Integrity
6 Antibiotics That Block Protein Synthesis
7 Antibiotics That Target DNA and RNA Information Transfer
8 Antibiotics That Block Biosynthesis of the DNA Building Block Deoxythymidylate
Section III Mechanisms: Bacterial Resistance to Antibiotics
9 Bacterial Antibiotic Resistance: Overview
10 Antibiotic Resistance: Modification or Destruction of the Antibiotic
11 Antibiotic Resistance via Membrane Efflux Pumps
12 Resistance via Target Modification 230
13 Tuberculosis: A Formidable Challenge for Antibiotic Therapy
Section IV Mechanisms: Antibiotic Biosynthesis
14 Antibiotic Biosynthesis: Principles
15 Biosynthesis of Peptide Antibiotics
16 Biosynthesis of Polyketide Antibiotics
17 Biosynthesis of Oligosaccharide, Isoprenoid and C-P Antibiotic Classes
Section V Opportunities
18 Underexploited Pathways and Targets for Antibiotics
19 Prospects for New Molecules and New Targets
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